- NBA Today - All the real world matchups, news and stats are automatically streamed right into your game providing dynamic commentary and presentation elements based upon what is happening in the real NBA.
- My Player Mode Create the ultimate NBA player and guide his every career move. Start as an undrafted rookie in the Summer Circuit; work hard enough and you may get an invite to participate in an NBA team's training camp, or you may end up in the D-League. The road to being an NBA star is a long and hard battle.
- Crews - Round up your friends and build the ultimate squad, using either your created players from My Player mode or an actual NBA team, then go online and battle other Crews for bragging rights and progression points as you try to climb your way to the top of the Crew leaderboard rankings.
- Living Rosters - The 2K Insider and his team of NBA analysts continue to keep NBA 2K10 fresh with up-to-date team and player information, including roster and lineup moves, trades, injuries and player ratings. Now track all of the changes through the season with interactive menus and analysis.
- Seamless Online Experience Forget the past, with NBA2K10 online play is fully incorporated into every mode of the game. Now you can play the AI, challenge the friend sitting next to you or play your buddy across town anytime, from anywhere in the game.
- Signature Play - Signature Play pulls together all of NBA 2K's player Signature Styles and adds in all-new Signature Tendencies and facial expressions, creating NBA 2K10 teams that play and react like their real life counterparts for an unbelievably realistic NBA experience.
- NEW Intuitive Offensive Controls - All-new easy-to-use dribbling and post game controls allow you to pull off ankle breaking Iso-Motion moves and dominate like Kobe from the perimeter to the paint.
- Shut Down D - Shut down teams down like never before with innovative defensive controls that allow you to shadow your opponent's every move, deny position off-ball, and even select how you want to contest shots.